Human Tumor-Derived Exosomes Selectively Impair Lymphocyte Responses to Interleukin-2
نویسندگان
چکیده
منابع مشابه
Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2.
Exosomes are nanometer-sized vesicles, secreted by normal and neoplastic cells. The outcome following interaction between the cellular immune system and cancer-derived exosomes is not well understood. Interleukin-2 (IL-2) is a key factor supporting expansion and differentiation of CTL and natural killer (NK) cells but can also support regulatory T cells and their suppressive functions. Our stud...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2007
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-3456